Isoflurane (pronounced “Isole”) is a compound of Isophthaloyl and Chloroform. Also known as octane, this compound is widely used in the cosmetic and pharmaceutical industries. The compound is known for its ability to prevent bacteria and viruses from attaching themselves to the skin’s surface. Its name comes from the fact that it crystallizes into tiny isoprene is frozen at negative temperature. As a result, the compound is not soluble, but becomes polar in nature when exposed to light.The global Isophthaloyl Chloride (ICL) market was valued at USD 1,761.2 Million in 2019 and is projected to reach USD 3,266.1 Million by 2027, expanding at a CAGR of 7.8% during the forecast period.
While the compound has many benefits, there are also some common questions that people ask about it. These include: Is Isophthaloyl chloride safe for use in personal care products? How does the chemical compare to other commonly used preservatives such as parabens and phthalates? What are the side effects of using isophthaloyl chloride? Can you get acne from isophthaloyl?
One of the most important things that you need to know about using this topical chemical is that it is safe to use. While scientists and dermatologists are still assessing the potential health hazards of isophthaloyl chloride, the substance is regarded as safe for use in cosmetics and health care products. It is believed to be slightly toxic to both humans and animals, but the only known effect so far is in relation to irritation of the skin. The irritation is thought to be caused by the hydrolysis process in which the active agent is generated and then metabolized in the liver.
Isophthaloyl and m-phthalyl chloride belong to different classes of chemical compounds with the primary difference being their chemical properties. M-Phthalate is a more stable version of isophthalic acid chloride. Both these chemicals are produced through different chemical reactions, although one is considered to be faster acting than the other. This faster-acting chemical is also believed to be more dangerous when combined with other substances such as chlorine and phenol that have similar hydrolytic properties.
The cosmetic industry has been making use of this agent since the late nineteenth century, where it is primarily used in the manufacture of skin care products. The reason behind its popularity is that it can help remove dead skin cells while leaving the fresher and more elastic skin intact. However, many dermatologists warn that pregnant women and people suffering from skin allergies should not use this chemical as it can cause serious problems for them. Dermatologists do however recommend its use in dilute form as it can help reduce redness and irritation of dry skin caused by eczema and other conditions. Isophthaloyl chloride is formed through an acylation reaction when m-phthalyl chloride is coupled with an amino acid called l-histidine.
When the two chemicals are mixed, the resulting product is known as phthalic acid or iso-phthalates. It is slightly soluble in water and can thus pass through gels and lipsticks without difficulty. Unlike the latter however, it is insoluble in fats and oils. Because of this property, it is commonly added to shampoos and hair packs as it makes the hair and scalp softer. However, like any chemical, it can be potentially toxic when taken internally.
The Food and Drug Administration approved the use of isophthaloyl chloride as a preservative in cosmetics and health care products. However, the agency has also set certain standards, mostly based on toxicity, for the amount of isophthaloyl chloride to be contained in these products. It is strictly enforced that cosmetics and health care products that contain this compound have at least 20 percent isopropyl alcohol in them. To ensure that the chemical is not absorbed by the body, isopropyl alcohol is added in very minute amounts. Also, if you are pregnant or nursing your child, you are advised to stay away from these products as well. With the rising case of COVID-19, the industry is seeing a slow growth. Hopefully, the JnJCovid vaccine will be out soon and shortage of vaccines will be over
Not all cosmetic products have the same safety guidelines, so it is best to read the label before buying. However, this chemical is generally recognized as safe, so you can put it on your skin. If you are allergic to isophthaloyl chloride, you can also use other alternatives that do not contain this ingredient. However, if you are using the mentioned products for a long period of time, it might be dangerous. If in doubt, always seek medical advice before using it.