The use of and the public allowance for any drug that can affect our overall body health, requires the complete knowledge of its chemical constituents, the constituents of physiological concern and the pharmacological importance of all of them. This helps us to understand the complete mechanism of action of the drug and its complete processing once we intake it.
Kratom is a natural herb basically known to produce complex stimulants and to show opioid like effects. Since its use was introduced among the public, the rate of opioid consumption has been declining continuously. It is used by the patients themselves to ease some kind of pain and to release body stress and sometimes it is prescribed by the physicians too.
The clinical prescription should include all of the knowledge of the daily habits of the user, its capacity and the individual impact the drug is likely to make on them.
Humans have been using plant based drugs for centuries, as they are naturally infused with very precious nutrients, elements and minerals. Even though these herbs and the remedies made out of them are not well studied regarding the component efficacies, their extensive use is still being noticed.
It is revealed by a recent study that 30% of US patients are on some herbal remedy. These kinds of drugs usually contain a number of pharmacologically active components and the chemical nature of those components is our basic concern.
Kratom consists of two of such chemicals, named as mitragynine and 7-hydroxymitragynine. Other components include speciociliatine, paynantheine and speciogynine.
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The basic function of mitragynine is to inhibit the radio-ligand attachment in the central nervous system and the proper activation of the noradrenergic and serotonergic pathways found in the spinal cord. It also stimulates postsynaptic adrenergic biochemical receptors and causes the blockage of 5-hydroxytryptamine receptors.
On the other hand, the second major component 7-hydroxymitragynine is capable of producing 13 folds higher chemical effects than morphine and 46 folds higher than the mitragynine. It owns this much high potency due to the presence of high energy –OH bond. This is the constituent responsible of causing some addiction to high dose intake of the drug in the regular users as its potency is notably dose-dependent.
This evergreen natural herb significantly owns a very unusual action of impacting the patients being a stimulant as well as a depressant. This activity depends upon the drug manifestation, individual response of the patients’ body and the severity of the ailment the patient is going through. The metabolic activity of the active constituents of the drug is very complex. The metabolism mechanisms of only the mitragynine are divided into phase 1 and phase 2 reactions.
Therefore the possible regulation of Authentic Kratom powders should be necessarily monitored continuously. Some of the techniques to screen the effects of Kratom constituents of the user’s body and systems are liquid chromatography-mass spectrophotometry for the overall analysis of the drug efficacy and potency as well.
The determination and the potential risks related to how it acts toxicologically, is the main concern of the physicians and health experts these days. This emerging biochemical agent is having a lot of growing concerns regarding its chemical abuse and the toxicity.
Kratom is known to be one of the fastest growing herbs in US. It is always interesting to seek some practical knowledge about all of the benefits and potential risks of something being used widely.
It should always be kept in mind that any remedy whether it is a natural one or a chemical one, everyone’s body has a distinct individual response to it based on the physiological functions and condition of the body systems.
