In his article “The Discovery of Jan Van Deursen,” Science magazine lauds Jan van Deursen, Ph.D., for mentoring many young scientists. A mentor provides the initial push to succeed, and young scientists often build on their mentor’s work. Jan van Deursen provided this boost to child researchers. He has been a mentor to many young scientists, including Dr. Childs. Jan van Deursen’s discovery will forever be remembered.
Jan van Deursen is a world-renowned American scientist who discovered a key cause of aging. His discovery is leading to groundbreaking treatments for age-related diseases. Born in the Netherlands, Jan Van Deursen began his research on stem cell editing in mice in the 1990s. In the US, he established his lab at St. Jude Children’s Research Hospital and later served as the Mayo Clinic’s director of a state-of-the-art gene knockout facility.
A pioneer in studying senescent cells, Dr. van Deursen’s research has been published in a prestigious scientific journal. In 2011, Jan Van Deursen co-founded Unity Biotechnology, a biotech company dedicated to translating his discoveries into effective therapies for age-related diseases. This breakthrough has already helped millions of people in various fields, including diabetes and cancer. The discovery has inspired many other scientists and helped pave the way for effective treatments.
As chair of the biochemistry department at Mayo Clinic, Jan van Deursen promoted diversity among faculty members. He filled 5 out of 6 open tenure-track positions with diverse candidates. Jan van Deursen also championed non-tenure track faculty. His efforts to improve mentoring and institutional support for non-tenured faculty helped make Mayo Clinic an inclusive workplace. His research lab remained incredibly diverse throughout his career.
Dr. Jan van Deursen applied these technologies to the treatment of cancer. Among the most notable advances he made was the discovery of a critical checkpoint protein called BubR1, which is required for faithful chromosome segregation in cells. This discovery has been implicated in cancer, age-related diseases, and progeria. He holds a Ph.D. in Cell Biology and blogs regularly.
Dr. Van Deursen’s work is now being supported by the Ellison Medical Foundation, a nonprofit organization established by Oracle co-founder Larry Ellison. Another foundation supporting the research is the Robert P. Kogod Foundation, a Washington-based philanthropist. Paul F. Glenn, a commodities trader, set up the Glenn Foundation, which provided an unsolicited $60,000 to support the research.
The research that Dr. Van Deursen performed on cancer cells at the Mayo Clinic is based on studies in mice. He developed mouse models that were prone to a chromosome abnormality. As a result of this research, he discovered that deleting these cells greatly improved the health of mice. This discovery may one day help humans as well. So, how can this groundbreaking work be applied to humans? It may help extend our life expectancy and improve our quality of life.
In 2000, Jan van Deursen produced transgenic mice with thin fur that didn’t develop tumors. They also had glazed eyes. Van Deursen’s team studied the causes of these mice’s aging and discovered that the mice had strange responsible cells. They could also help us in understanding the aging process. It is important to note that this work is only a small portion of the bigger picture.
After completing his studies on mice, Van Deursen’s atherosclerosis research has positively impacted our health. Genetically modified mice were used to test the role of senescent cells in atherosclerosis. Previous studies had debated whether these cells were responsible for plaque formation. Van Deursen’s study involved genetically engineered mice that eat a fat-rich diet. The mice were then given the drug that kills off the senescent cells. The results showed that these mice significantly decreased the risk of heart attacks and strokes.
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